Synthesis of inhibitors of the NS3 serine proteases from Dengue and West Nile Flaviviruses

The application of NMR spectroscopy to the elucidation of solution structure/conformation of small peptides and peptido-organic hybrids

Virtual screening, principally applied to protease, GPCR, and kinase targets

Molecular modeling

Inhibitors of human non-secretory phospholipase A2

The synthesis of small rigid hydrophobic cavitands as enzyme mimetics

The synthesis of inhibitors of HIV-1 proteinase as potential therapeutics for the treatment of AIDS

The synthesis of small non-steroidal antiinflammatory drugs as arthritis therapeutics

New methods of heterocyclic synthesis

The study of reactive organometallic intermediates by heteronuclear nmr spectroscopy

The syntheses of non-toxic derivatives and analogues of epibatidine

Development of novel anti-schizophrenic drugs


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